Cumulative Blood Pressure Exposure, Basal Ganglia, and Thalamic Morphology in Midlife.

ABSTRACT: High blood pressure (BP) negatively affects brain structure and function. Hypertension is associated with white matter hyperintensities, cognitive and mobility impairment in late-life. However, the impact of BP exposure from young adulthood on brain structure and function in mid-life is unclear. Identifying early brain structural changes associated with BP exposure, before clinical onset of cognitive dysfunction and mobility impairment, is essential for understanding mechanisms and developing interventions. We examined the effect of cumulative BP exposure from young adulthood on brain structure in a substudy of 144 (61 female) individuals from the CARDIA (Coronary Artery Risk Development in Young Adults) study. At year 30 (Y₃₀, ninth visit), participants (56±4 years old) complet

SUBMITTER: Jenkins LM 

PROVIDER: S-EPMC8189649 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature