Targeting a highly conserved domain in bacterial histidine kinases to generate inhibitors with broad spectrum activity.

ABSTRACT: With the rise in antimicrobial resistance and the dearth of effective strategies to combat this threat, the development of novel therapies is of utmost importance. Targeting of bacterial signaling through their the two-component systems (TCSs) may be a viable strategy. TCSs are comprised of a sensory histidine kinase (HK), of which a bacterium can have up to 160 distinct proteins, and a cognate response regulator (RR). The TCSs are generally non-essential for life, but control many virulence and antibiotic-resistance mechanisms. This, along with their absence in animals makes the TCSs an attractive target for antimicrobial therapy, whether as a stand-alone treatments or adjuvants for existing therapies. This review focuses on progress in the development of inhibitors that target the HK ATP

SUBMITTER: Fihn CA 

PROVIDER: S-EPMC8189720 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature