Entry-inhibitory role of catechins against SARS-CoV-2 and its UK variant.

ABSTRACT:

Background

The global pandemic caused by a RNA virus capable of infecting humans and animals, has resulted in millions of deaths worldwide. Severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) infects the lungs, and the gastrointestinal tract to some extent. Rapid structural mutations have increased the virulence and infectivity of the virus drastically. One such mutated strain known as the UK variant has caused many deaths in the United Kingdom.

Hypothesis

Among several indigenous natural ingredients used for prevention and cure of many diseases, the catechins have been reported for their antiviral activity, even against SARS-CoV-2. Characteristic mutations present on the spike protein have presented the newer strain its enhanced infectivity. The spike protein help

SUBMITTER: Mhatre S 

PROVIDER: S-EPMC8189743 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature