Effects of recipient age, heparin release and allogeneic bone marrow-derived stromal cells on vascular graft remodeling.

ABSTRACT: Small-caliber vascular grafts are used in a wide range of clinical conditions. However, there remains a substantial unfulfilled need for readily-available, synthetic vascular grafts with high long-term patency rate. To fulfill the translational goal for bioengineered vascular grafts, important considerations for the pre-clinical evaluation include the graft design, cell incorporation and selection of an animal model. To assess the three factors, we used vascular grafts consisting of core/shell-structured microfibers of polycaprolactone/gelatin with a thin polycaprolactone overlay. The respective influences of the heparin release mode, animal age, and allogeneic bone marrow-derived stromal cells (MSCs) seeded in the lumen on the graft remodeling were assessed after four-and-half-month impla

SUBMITTER: Johnson R 

PROVIDER: S-EPMC8189838 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature