Speciation analysis of organoarsenic species in marine samples: method optimization using fractional factorial design and method validation.

ABSTRACT: Organoarsenic species in marine matrices have been studied for many years but knowledge gaps still exist. Most literature focuses on monitoring of arsenic (As) species using previously published methods based on anion- and cation-exchange high-performance liquid chromatography-inductively coupled plasma mass spectrometry (HPLC-ICP-MS). These studies are often limited to few As species and/or only specific method performance characteristics are described. Most marine certified reference materials (CRMs) are only certified for arsenobetaine (AB) and dimethylarsinate (DMA), making it difficult to evaluate the accuracy of analytical methods for other organoarsenic species. To address these gaps, the main objective of this work was to develop and validate a method for speciation analysis of a b

SUBMITTER: Tibon J 

PROVIDER: S-EPMC8189937 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature