The increasing importance of histologic grading in tailoring adjuvant systemic therapy in 30,843 breast cancer patients.

ABSTRACT:

Purpose

The large variation in histologic grading of invasive breast cancer (IBC) that has been reported likely influences tailoring adjuvant therapy. The role of grading in therapeutic decision-making in daily practice, was evaluated using the Dutch national guidelines for IBC-management.

Methods

Synoptic reports of IBC resection-specimens, obtained between 2013 and 2016, were extracted from the nationwide Dutch Pathology Registry, and linked to treatment-data from the Netherlands Cancer Registry. The relevance of grading for adjuvant chemotherapy (aCT) was quantified by identifying patients for whom grade was the determinative factor. In addition, the relation between grade and aCT-administration was evaluated by multivariate logistic regression for patients with a guideli

SUBMITTER: van Dooijeweert C 

PROVIDER: S-EPMC8189961 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature