Resuscitative Effect of Centhaquine (Lyfaquin^®) in Hypovolemic Shock Patients: A Randomized, Multicentric, Controlled Trial.

ABSTRACT:

Introduction

Centhaquine (Lyfaquin^®) showed significant efficacy as a resuscitative agent in animal models of haemorrhagic shock. Its safety and tolerability were confirmed in healthy human volunteers. In this study, our primary objective was to determine the safety, and the secondary objective was to assess the efficacy of centhaquine in patients with hypovolemic shock.

Methods

A prospective, multicentre, randomized phase II study was conducted in male and female patients aged 18-70 years with hypovolemic shock having systolic BP ≤ 90 mmHg. Patients were randomized in a 1:1 ratio to either the control or centhaquine group. The control group received 100 ml of normal saline infusion over 1 h, while the centhaquine group received 0.01 mg/kg of centhaquine in 100 ml

SUBMITTER: Gulati A 

PROVIDER: S-EPMC8189997 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature