Computational and experimental studies of a cell-imprinted-based integrated microfluidic device for biomedical applications.

ABSTRACT: It has been proved that cell-imprinted substrates molded from template cells can be used for the re-culture of that cell while preserving its normal behavior or to differentiate the cultured stem cells into the template cell. In this study, a microfluidic device was presented to modify the previous irregular cell-imprinted substrate and increase imprinting efficiency by regular and objective cell culture. First, a cell-imprinted substrate from template cells was prepared using a microfluidic chip in a regular pattern. Another microfluidic chip with the same pattern was then aligned on the cell-imprinted substrate to create a chondrocyte-imprinted-based integrated microfluidic device. Computational fluid dynamics (CFD) simulations were used to obtain suitable conditions for injecting cells

SUBMITTER: Yazdian Kashani S 

PROVIDER: S-EPMC8190060 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature