Menopause impacts human brain structure, connectivity, energy metabolism, and amyloid-beta deposition.

ABSTRACT: All women undergo the menopause transition (MT), a neuro-endocrinological process that impacts aging trajectories of multiple organ systems including brain. The MT occurs over time and is characterized by clinically defined stages with specific neurological symptoms. Yet, little is known of how this process impacts the human brain. This multi-modality neuroimaging study indicates substantial differences in brain structure, connectivity, and energy metabolism across MT stages (pre-menopause, peri-menopause, and post-menopause). These effects involved brain regions subserving higher-order cognitive processes and were specific to menopausal endocrine aging rather than chronological aging, as determined by comparison to age-matched males. Brain biomarkers largely stabilized post-menopause, and

SUBMITTER: Mosconi L 

PROVIDER: S-EPMC8190071 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature