Lower total motile count is associated with smaller historic intergenerational family size: a pedigree analysis from the Utah Population Database.

ABSTRACT:

Purpose

To describe the association between contemporary total motile count (TMC), a measure of male factor infertility, and historic intergenerational family size.

Methods

This is a retrospective, population-based, cohort study of men who underwent semen analysis for infertility workup at University of Utah, with at least a single measure of TMC, who were linked to extensive genealogical data. Two thousand one hundred eighty-two pedigree branches of men with a measure of TMC within the UPDB were identified. We identified the average number of generations and offspring within each generation. Conditional logistic regression models were used to assess the association between the risk of having a TMC in the 5th or 25th percentile and intergenerational family size. Generalized

SUBMITTER: Patel DP 

PROVIDER: S-EPMC8190225 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature