Detection of glioma infiltration at the tumor margin using quantitative stimulated Raman scattering histology.

ABSTRACT: In the management of diffuse gliomas, the identification and removal of tumor at the infiltrative margin remains a central challenge. Prior work has demonstrated that fluorescence labeling tools and radiographic imaging are useful surgical adjuvants with macroscopic resolution. However, they lose sensitivity at the tumor margin and have limited clinical utility for lower grade histologies. Fiber-laser based stimulated Raman histology (SRH) is an optical imaging technique that provides microscopic tissue characterization of unprocessed tissues. It remains unknown whether SRH of tissues taken from the infiltrative glioma margin will identify microscopic residual disease. Here we acquired glioma margin specimens for SRH, histology, and tumor specific tissue characterization. Generalized linea

SUBMITTER: Pekmezci M 

PROVIDER: S-EPMC8190264 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature