Strong Correlation of MTHFR Gene Polymorphisms with Breast Cancer and its Prognostic Clinical Factors among Egyptian Females.

ABSTRACT:

Introduction

Globally, Breast cancer (BC) is considered the second most common type of cancer and the principal cause of death among affected women.

Aim

In this study, we targeted to demonstrate the association of MTHFR single gene polymorphisms (SNPs) with the susceptibility of breast cancer, in addition to its correlation with the clinical patient features.

Patients and methods

This work was conducted on 100 Egyptian females with breast cancer and 60 healthy matched controls. Clinical examinations and pathological investigations were recorded. Genotyping of MTHFR polymorphisms C677T (rs1801133) and A1298C (rs1801131) by using Restriction Fragment length Polymorphisms (RFLP) and Sequencing assays were performed. Univariate, Multivariate and Haplotype analysis for the

SUBMITTER: Omran MH 

PROVIDER: S-EPMC8190368 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature