Association of Premature Immune Aging and Cytomegalovirus After Solid Organ Transplant.

ABSTRACT: Immune function is altered with increasing age. Infection with cytomegalovirus (CMV) accelerates age-related immunological changes resulting in expanded oligoclonal memory CD8 T cell populations with impaired proliferation, signaling, and cytokine production. As a consequence, elderly CMV seropositive (CMV⁺) individuals have increased mortality and impaired responses to other infections in comparison to seronegative (CMV^-) individuals of the same age. CMV is also a significant complication after organ transplantation, and recent studies have shown that CMV-associated expansion of memory T cells is accelerated after transplantation. Thus, we investigated whether immune aging is accelerated post-transplant, using a combination of telomere length, flow cytometry phenotyp

SUBMITTER: Higdon LE 

PROVIDER: S-EPMC8190404 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature