Gain-of-function Tibetan PHD2^D4E;C127S variant suppresses monocyte function: A lesson in inflammatory response to inspired hypoxia.

ABSTRACT:

Background

We have previously described an evolutionarily selected Tibetan prolyl hydroxylase-2 (PHD2^D4E;C127S) variant that degrades the hypoxia-inducible factor (HIFα) more efficiently and protects these highlanders from hypoxia-triggered elevation in haemoglobin concentration. High altitude is known to cause acute mountain sickness (AMS) and high-altitude pulmonary edema (HAPE) in a section of rapidly ascending non-acclimatised lowlanders. These morbidities are often accompanied by inflammatory response and exposure to hypobaric hypoxia is presumed to be the principal causative agent. We have investigated whether PHD2^D4E;C127S variant is associated with prevention of hypoxia-mediated inflammatory milieu in Tibetan highlanders and therefore identify a potent

SUBMITTER: Bhattacharya S 

PROVIDER: S-EPMC8190441 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature