Myosin cross-bridge kinetics slow at longer muscle lengths during isometric contractions in intact soleus from mice.

ABSTRACT: Muscle contraction results from force-generating cross-bridge interactions between myosin and actin. Cross-bridge cycling kinetics underlie fundamental contractile properties, such as active force production and energy utilization. Factors that influence cross-bridge kinetics at the molecular level propagate through the sarcomeres, cells and tissue to modulate whole-muscle function. Conversely, movement and changes in the muscle length can influence cross-bridge kinetics on the molecular level. Reduced, single-molecule and single-fibre experiments have shown that increasing the strain on cross-bridges may slow their cycling rate and prolong their attachment duration. However, whether these strain-dependent cycling mechanisms persist in the intact muscle tissue, which encompasses more compl

SUBMITTER: Fenwick AJ 

PROVIDER: S-EPMC8190544 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature