Genomic epidemiology of a <i>Cryptococcus neoformans</i> case cluster in Glasgow, Scotland, 2018.

ABSTRACT: In 2018, a cluster of two cases of cryptococcosis occurred at the Queen Elizabeth University Hospital (QEUH) in Glasgow, Scotland (UK). It was postulated that these cases may have been linked to pigeon droppings found on the hospital site, given there have been previous reports of Cryptococcus neoformans associated with pigeon guano. Although some samples of pigeon guano taken from the site yielded culturable yeast from genera related to Cryptococcus, they have since been classified as Naganishia or Papiliotrema spp., and no isolates of C. neoformans were recovered from either the guano or subsequent widespread air sampling. In an attempt to further elucidate any possible shared source of the clinical isolates, we used whole-genome sequencing and phylogen

SUBMITTER: Farrer RA 

PROVIDER: S-EPMC8190611 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature