A high prevalence of <i>bla</i>_OXA-48 in <i>Klebsiella</i> (<i>Raoultella</i>) <i>ornithinolytica</i> and related species in hospital wastewater in South West England.

ABSTRACT: Klebsiella species occupy a wide range of environmental and animal niches, and occasionally cause opportunistic infections that are resistant to multiple antibiotics. In particular, Klebsiella pneumoniae (Kpne) has gained notoriety as a major nosocomial pathogen, due principally to the rise in non-susceptibility to carbapenems and other beta-lactam antibiotics. Whilst it has been proposed that the urban water cycle facilitates transmission of pathogens between clinical settings and the environment, the level of risk posed by resistant Klebsiella strains in hospital wastewater remains unclear. We used whole genome sequencing (WGS) to compare Klebsiella species in contemporaneous samples of wastewater from an English hospital and influent to the associated

SUBMITTER: Gibbon MJ 

PROVIDER: S-EPMC8190614 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature