Association of Chemotherapy Timing in Pregnancy With Congenital Malformation.

ABSTRACT:

Importance

Chemotherapy during the first trimester of pregnancy should be avoided owing to the risk of congenital malformations. However, the precise gestational age at which chemotherapy can be initiated safely remains unclear.

Objective

To assess congenital malformation rates associated with gestational age at initiation of chemotherapy among pregnant women with cancer.

Design, setting, and participants

This multicenter cohort study evaluated all pregnant women who received chemotherapy between 1977 and 2019 registered in the International Network on Cancer, Infertility and Pregnancy (INCIP) database. Data were analyzed from February 15 to June 2, 2020.

Exposures

Cancer treatment with chemotherapy during pregnancy.

Main outcomes and measures

Analysis w

SUBMITTER: van Gerwen M 

PROVIDER: S-EPMC8190627 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature