Trophoblast-secreted soluble-PD-L1 modulates macrophage polarization and function.

ABSTRACT: Decidual macrophages are in close contact with trophoblast cells during placenta development, and an appropriate crosstalk between these cellular compartments is crucial for the establishment and maintenance of a healthy pregnancy. During different phases of gestation, macrophages undergo dynamic changes to adjust to the different stages of fetal development. Trophoblast-secreted factors are considered the main modulators responsible for macrophage differentiation and function. However, the phenotype of these macrophages induced by trophoblast-secreted factors and the factors responsible for their polarization has not been elucidated. In this study, we characterized the phenotype and function of human trophoblast-induced macrophages. Using in vitro models, we found that human trophoblast-e

SUBMITTER: Zhang YH 

PROVIDER: S-EPMC8190653 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature