Macrophage biomimetic nanocarriers for anti-inflammation and targeted antiviral treatment in COVID-19.

ABSTRACT:

Background

The worldwide pandemic of COVID-19 remains a serious public health menace as the lack of efficacious treatments. Cytokine storm syndrome (CSS) characterized with elevated inflammation and multi-organs failure is closely correlated with the bad outcome of COVID-19. Hence, inhibit the process of CSS by controlling excessive inflammation is considered one of the most promising ways for COVID-19 treatment.

Results

Here, we developed a biomimetic nanocarrier based drug delivery system against COVID-19 via anti-inflammation and antiviral treatment simultaneously. Firstly, lopinavir (LPV) as model antiviral drug was loaded in the polymeric nanoparticles (PLGA-LPV NPs). Afterwards, macrophage membranes were coated on the PLGA-LPV NPs to constitute drugs loaded macrophage

SUBMITTER: Tan Q 

PROVIDER: S-EPMC8190731 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature