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Multiomics Imaging Using High-Energy Water Gas Cluster Ion Beam Secondary Ion Mass Spectrometry [(H₂O)_n-GCIB-SIMS] of Frozen-Hydrated Cells and Tissue.

ABSTRACT: Integration of multiomics at the single-cell level allows the unambiguous dissecting of phenotypic heterogeneity at different states such as health, disease, and biomedical response. Imaging mass spectrometry holds the promise of being able to measure multiple types of biomolecules in parallel in the same cell. We have explored the possibility of using water gas cluster ion beam secondary ion mass spectrometry [(H₂O)_n-GCIB-SIMS] as an analytical tool for multiomics assay. (H₂O)_n-GCIB has been hailed as an ideal ionization source for biological sampling owing to the enhanced chemical sensitivity and reduced matrix effect. Taking advantage of 1 μm spatial resolution by using a high-energy beam system, we have clearly shown the enhance

SUBMITTER: Tian H

PROVIDER: S-EPMC8190772 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature

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Multiomics Imaging Using High-Energy Water Gas Cluster Ion Beam Secondary Ion Mass Spectrometry [(H₂O)_n-GCIB-SIMS] of Frozen-Hydrated Cells and Tissue.

OmicsDI is part of the ELIXIR infrastructure

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Dataset Information

Multiomics Imaging Using High-Energy Water Gas Cluster Ion Beam Secondary Ion Mass Spectrometry [(H2O)n-GCIB-SIMS] of Frozen-Hydrated Cells and Tissue.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Multiomics Imaging Using High-Energy Water Gas Cluster Ion Beam Secondary Ion Mass Spectrometry [(H₂O)_n-GCIB-SIMS] of Frozen-Hydrated Cells and Tissue.