Association between baseline and changes in serum uric acid and incident metabolic syndrome: a nation-wide cohort study and updated meta-analysis.

ABSTRACT:

Background

To prospectively examine the associations of baseline serum uric acid (SUA) and SUA changes with incident metabolic syndrome (MetS) and update the evidence through a meta-analysis.

Methods

Our analyses were based on the China Health and Retirement Longitudinal Study from 2011-2012 to 2015-2016. The exposures were baseline SUA and SUA changes, and the outcome was incident MetS assessed in 2015-2016. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). A meta-analysis was conducted to synthesize evidence from all cohort studies on the same topic.

Results

Of 3779 participants (47.2% men; mean age: 59.5 years) without MetS, 452 participants developed MetS after a follow-up of 4 years. Compared to the lowest quartiles, t

SUBMITTER: Chen S 

PROVIDER: S-EPMC8191036 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature