Exposure to Low to Moderate Doses of Ionizing Radiation Induces A Reduction of Pro-Inflammatory Ly6chigh Monocytes and a U-Curved Response of T Cells in APOE -/- Mice.

ABSTRACT: Low dose ionizing radiation (LDIR) is known to have a protective effect on atherosclerosis in rodent studies, but how it impacts different cells types involved in lesion formation remains incompletely understood. We investigated the immunomodulatory response of different doses and dose-rates of irradiation in ApoE^-/- mice. Mice were exposed to external γ rays at very low (1.4 mGy.h^-1) or low (50 mGy.h^-1) dose-rates, with cumulative doses spanning 50 to 1000 mGy. Flow cytometry of circulating cells revealed a significant decrease in pro-inflammatory Ly6C^Hi monocytes at all cumulative doses at low dose-rate, but more disparate effects at very low dose-rate with reductions in Ly6C^Hi cells at doses of 50, 100 and 750 mGy only. In contrast,

SUBMITTER: Rey N 

PROVIDER: S-EPMC8191078 | biostudies-literature | 2021 Apr-Jun

REPOSITORIES: biostudies-literature