Increased whiB7 expression and antibiotic resistance in Mycobacterium chelonae carrying two prophages.

ABSTRACT:

Background

The global rise in the incidence of non-tuberculosis mycobacterial infections is of increasing concern due their high levels of intrinsic antibiotic resistance. Although integrated viral genomes, called prophage, are linked to increased antibiotic resistance in some bacterial species, we know little of their role in mycobacterial drug resistance.

Results

We present here for the first time, evidence of increased antibiotic resistance and expression of intrinsic antibiotic resistance genes in a strain of Mycobacterium chelonae carrying prophage. Strains carrying the prophage McProf demonstrated increased resistance to amikacin. Resistance in these strains was further enhanced by exposure to sub-inhibitory concentrations of the antibiotic, acivicin, or by the presenc

SUBMITTER: Cushman J 

PROVIDER: S-EPMC8191103 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature