Diagnostic utility of STAT6^YE361 expression in classical Hodgkin lymphoma and related entities.

ABSTRACT: Although the distinction of classical Hodgkin lymphoma from nodular lymphocyte predominant Hodgkin lymphoma using morphology and immunostains is straightforward in most instances, occasional cases pose diagnostic challenge. We sought to determine the utility of the novel YE361 STAT6 rabbit monoclonal antibody in Hodgkin lymphoma and diagnostically challenging B- and T-cell non-Hodgkin lymphoma entities with Hodgkin-like features. Cases from seven institutions included: 57 classical Hodgkin lymphomas (31% EBV+), 34 nodular lymphocyte predominant Hodgkin lymphomas, 34 mimicking B- and T-cell non-Hodgkin lymphomas, and 7 reactive lymphoproliferations. After review of histology, STAT6^YE361 immunostaining was performed. The intensity and spatial localization of immunopositivity was a

SUBMITTER: Van Slambrouck C 

PROVIDER: S-EPMC8191386 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature