A Combined Long Noncoding RNA Signature as a Candidate Prognostic Biomarker for Ovarian Cancer.

ABSTRACT:

Aims

Dysregulated long noncoding RNAs (lncRNAs) contributing to ovarian cancer (OC) development may serve as prognostic biomarker. We aimed to explore a lncRNA signature to serve as prognostic biomarker of OC.

Methods

Univariate Cox regression was conducted on the lncRNA expression dataset from the TCGA cohort, and 246 genes significantly associated with survival were retained for building a model. A random forest survival model was carried out, and a model was developed using 6 genes with the highest frequency. The selected genes were applied in a Cox multivariate regression model for prognostic prediction by calculating the risk score. We also used CCK-8, EdU, and colony formation assays to validate the function of these lncRNAs in OC cells.

Results

This study confi

SUBMITTER: Li H 

PROVIDER: S-EPMC8191461 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature