Oral microbiome and onset of oral mucositis in patients with squamous cell carcinoma of the head and neck.

ABSTRACT:

Background

Oral mucositis (OM) is a debilitating sequela for patients treated for squamous cell carcinoma of the head and neck (HNSCC). This study investigated whether oral microbial features before treatment or during treatment are associated with the time to onset of severe OM in patients with HNSCC.

Methods

This was a cohort study of newly diagnosed patients with locoregional HNSCC who received chemotherapy with or without radiotherapy from April 2016 to September 2017. OM was based on the National Cancer Institute's Common Terminology Criteria for Adverse Events, version 4.0. The oral microbiome was characterized on the basis of the 16S ribosomal RNA V4 region with the Illumina platform. A mixture cure model was used to generate hazard ratios for the onset of severe OM.<

SUBMITTER: Reyes-Gibby CC 

PROVIDER: S-EPMC8191575 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature