Ontology highlight
ABSTRACT:
SUBMITTER: Saha A
PROVIDER: S-EPMC8191777 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
Saha Arpita A Gaurav Amit Kumar AK Pandya Unnati M UM Afrin Marjia M Sandhu Ranjodh R Nanavaty Vishal V Schnur Brittny B Li Bibo B
Nucleic acids research 20210601 10
Telomere repeat-containing RNA (TERRA) has been identified in multiple organisms including Trypanosoma brucei, a protozoan parasite that causes human African trypanosomiasis. T. brucei regularly switches its major surface antigen, VSG, to evade the host immune response. VSG is expressed exclusively from subtelomeric expression sites, and we have shown that telomere proteins play important roles in the regulation of VSG silencing and switching. In this study, we identify several unique features o ...[more]