Hookworm treatment induces a decrease of suppressive regulatory T cell associated with a Th2 inflammatory response.

ABSTRACT:

Background

Like other helminths, hookworms (HW) induce a regulatory immune response able to modulate and dampen reactivity of the host to antigens. No data about the evolution of the immune response after treatment are available. We aim to phenotype the regulatory immune response during natural HW infection and its evolution after treatment.

Methodology

Twenty hookworm infected (HW+) and 14 non-infected subjects HW-from endemic area in the periphery of Ho Chi Minh City were included. Blood and feces samples were obtained before, 2 and 4 weeks after treatment with Albendazole 400mg. Additional samples were obtained at 3 and 12 months in the HW+ group. Hematological parameters, Treg (CD4+CD25hiFoxP3hi) and surface molecules (CD39, CD62L, ICOS, PD-1, CD45RA) were measured as we

SUBMITTER: Doyen V 

PROVIDER: S-EPMC8191899 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature