P2RX7 gene variation mediates the effect of childhood adversity and recent stress on the severity of depressive symptoms.

ABSTRACT: The P2X purinoceptor 7 (P2RX7) mediates inflammatory microglial responses and is implicated in neuroimmune mechanisms of depression and neurodegenerative disorders. A number of studies suggest that psychosocial stress may precipitate depression through immune activation. Genetic association studies of P2RX7 variants with depression have been inconclusive. However, nearly all studies have focused on only one single-nucleotide polymorphism (SNP) and have not considered interaction with psychosocial stress. We investigated the effect of several variations in P2RX7 gene using a clumping method in interaction with early adversities and recent stress on depression severity. 1752 subjects provided information on childhood adversities, recent life events, and current depression severity. Participa

SUBMITTER: Kristof Z 

PROVIDER: S-EPMC8191953 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature