Impact of metformin on survival outcome in ovarian cancer: a nationwide population-based cohort study.

ABSTRACT:

Objective

Investigation of new drugs (INDs) is a tremendously inefficient process in terms of time and cost. Drug repositioning is another method used to investigate potential new agents in well-known drugs. This study assessed the survival impact of metformin medication on ovarian cancer.

Methods

A national sample cohort of the Korean National Health Insurance Service Data was analyzed. Cox proportional hazards regression was used to analyzing hazard ratios (HRs) and 95% confidence intervals (CIs) after adjusting for underlying diseases and medications as confounding factors for overall survival (OS) and cancer-specific survival (CSS).

Results

A total of 866 eligible patients were included from among 1,025,340 cohort participants. Among them, 101 (11.7%) were metform

SUBMITTER: Park JY 

PROVIDER: S-EPMC8192236 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature