Does treatment with bisphosphonates protect against fractures in real life? The HUNT study, Norway.

ABSTRACT: Bisphosphonates reduce fractures in randomized controlled trials (RCT); however, there is less information from real life. In our population including 14,990 women and 13,239 men, use of bisphosphonates reduced risk of fractures in hip and forearm in women. The magnitude of the effect was comparable to results from RCT.

Introduction

The objective was to examine if treatment with bisphosphonates (BPs) was associated with reduced risk of fractures in the hip and forearm in women and men in the general population.

Methods

In a cohort study based on data from the third wave of the population-based HUNT Study (HUNT3), the fracture registry in Nord-Trøndelag, and the Norwegian Prescription Database, 14,990 women and 13,239 men 50-85 years were followed from the date of participatin

SUBMITTER: Hoff M 

PROVIDER: S-EPMC8192327 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature