A clinical evaluation of VO₂ kinetics in kidney transplant recipients.

ABSTRACT:

Purpose

Aerobic exercise capacity is reduced in patients with chronic kidney disease, partly due to alterations at the muscular and microvascular level. This study evaluated oxygen uptake (VO₂) kinetics as indicator of muscular oxidative metabolism in a population of Kidney Transplant Recipients (KTRs).

Methods

Two groups of KTRs enrolled 3 (n = 21) and 12 months (n = 14) after transplantation and a control group of healthy young adults (n = 16) underwent cardiopulmonary exercise testing on cycle-ergometer. The protocol consisted in two subsequent constant, moderate-load exercise phases with a final incremental test until exhaustion.

Results

The time constant of VO₂ kinetics was slower in KTRs at 3 and 12 months after transplantation compared to

SUBMITTER: Patti A 

PROVIDER: S-EPMC8192378 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature