Amygdala hyperconnectivity in the paranoid state: A transdiagnostic study.

ABSTRACT:

Background

Paranoia significantly contributes to social impairments across clinical diagnoses, and amygdala dysfunction has been identified as a neurobiological marker of paranoia among individuals with schizophrenia. Therefore, we aimed to investigate amygdala functional connectivity (FC) in paranoia across diagnoses.

Methods

Forty-five patients with recent history of clinically significant paranoid ideation and a current DSM-5 diagnosis of any disorder underwent resting-state functional magnetic resonance imaging either in a paranoid (N = 23) or non-paranoid (N = 22) state. Amygdala FC were compared between paranoid and non-paranoid patients. Supplemental correlation analyses between amygdala FC and paranoia score were performed separately in patients and a non-equivalent

SUBMITTER: Fan L 

PROVIDER: S-EPMC8192453 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature