Microbiota regulate innate immune signaling and protective immunity against cancer.

ABSTRACT: Microbiota play critical roles in regulating colitis and colorectal cancer (CRC). However, it is unclear how the microbiota generate protective immunity against these disease states. Here, we find that loss of the innate and adaptive immune signaling molecule, TAK1, in myeloid cells (Tak1^ΔM/ΔM) yields complete resistance to chemical-induced colitis and CRC through microbiome alterations that drive protective immunity. Tak1^ΔM/ΔM mice exhibit altered microbiota that are critical for resistance, with antibiotic-mediated disruption ablating protection and Tak1^ΔM/ΔM microbiota transfer conferring protection against colitis or CRC. The altered microbiota of Tak1^ΔM/ΔM mice promote IL-1β and IL-6 signaling pathways, which are required for induction of pr

SUBMITTER: Xing C 

PROVIDER: S-EPMC8192480 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature