Identifying molecular targets for reverse aging using integrated network analysis of transcriptomic and epigenomic changes during aging.

ABSTRACT: Aging is associated with widespread physiological changes, including skeletal muscle weakening, neuron system degeneration, hair loss, and skin wrinkling. Previous studies have identified numerous molecular biomarkers involved in these changes, but their regulatory mechanisms and functional repercussions remain elusive. In this study, we conducted next-generation sequencing of DNA methylation and RNA sequencing of blood samples from 51 healthy adults between 20 and 74 years of age and identified aging-related epigenetic and transcriptomic biomarkers. We also identified candidate molecular targets that can reversely regulate the transcriptomic biomarkers of aging by reconstructing a gene regulatory network model and performing signal flow analysis. For validation, we screened public experim

SUBMITTER: Lee HY 

PROVIDER: S-EPMC8192508 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature