Age-related central gain compensation for reduced auditory nerve output for people with normal audiograms, with and without tinnitus.

ABSTRACT: Central gain compensation for reduced auditory nerve output has been hypothesized as a mechanism for tinnitus with a normal audiogram. Here, we investigate if gain compensation occurs with aging. For 94 people (aged 12-68 years, 64 women, 7 tinnitus) with normal or close-to-normal audiograms, the amplitude of wave I of the auditory brainstem response decreased with increasing age but was not correlated with wave V amplitude after accounting for age-related subclinical hearing loss and cochlear damage, a result indicative of age-related gain compensation. The correlations between age and wave I/III or III/V amplitude ratios suggested that compensation occurs at the wave III generator site. For each one of the seven participants with non-pulsatile tinnitus, the amplitude of wave I, wave V, a

SUBMITTER: Johannesen PT 

PROVIDER: S-EPMC8192693 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature