Ontology highlight
ABSTRACT:
SUBMITTER: Nasirzade J
PROVIDER: S-EPMC8192760 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
Nasirzade Jila J Kargarpour Zahra Z Mitulović Goran G Strauss Franz Josef FJ Panahipour Layla L Schwarz Frank F Gruber Reinhard R
Scientific reports 20210610 1
Particulate autologous tooth roots are increasingly used for alveolar bone augmentation; however, the proteomic profile of acid dentin lysate and the respective cellular response have not been investigated. Here we show that TGF-β1 is among the 226 proteins of acid dentin lysate (ADL) prepared from porcine teeth. RNA sequencing identified 231 strongly regulated genes when gingival fibroblasts were exposed to ADL. Out of these genes, about one third required activation of the TGF-β receptor type ...[more]