Aberrant dynamics of cognitive control and motor circuits predict distinct restricted and repetitive behaviors in children with autism.

ABSTRACT: Restricted and repetitive behaviors (RRBs) are a defining clinical feature of autism spectrum disorders (ASD). RRBs are highly heterogeneous with variable expression of circumscribed interests (CI), insistence of sameness (IS) and repetitive motor actions (RM), which are major impediments to effective functioning in individuals with ASD; yet, the neurobiological basis of CI, IS and RM is unknown. Here we evaluate a unified functional brain circuit model of RRBs and test the hypothesis that CI and IS are associated with aberrant cognitive control circuit dynamics, whereas RM is associated with aberrant motor circuit dynamics. Using task-free fMRI data from 96 children, we first demonstrate that time-varying cross-network interactions in cognitive control circuit are significantly reduced an

SUBMITTER: Supekar K 

PROVIDER: S-EPMC8192778 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature