Dataset Information

Alterations in biochemical markers in adenovirus infection.

ABSTRACT:

Background

Analyze possible relationships between HAdV and markers for inflammation, specifically the C-reactive protein (CRP) and procalcitonin (PCT) tests, along with other haematological markers.

Methods

Retrospective study of 487 children presenting with fever and/or acute respiratory symptoms in the Paediatric Emergency Department. Analyses included viral presence/absence (both HAdV and other respiratory viruses) in respiratory exudates, CRP and PCT alterations in plasma, and haematological markers in whole blood.

Results

Viral load was >500 copies/10³ cells of HAdV in 127 cases (26.1%), of which 66 (52%, P<0.0001) had alterations in PCT, and 112 (88.1%, P<0.0001) in CRP. Haematological markers were similar either HAdV was present or not, although many HAdV positive patients demonstrated leukocytosis (66%). Bacterial cultures from 141 samples showed altered PCT in 27 (60%) with HAdV infection, in 3 (18.7%) with bacterial infection, and 13 (26.5%) without either viral or bacterial infection (P<0.05). CRP was altered in 88.9% of HAdV infected children and in 87% infected with bacteria, although the percentage was greater than in cases where other respiratory viruses were present (61.3% P<0.05).

Conclusions

Results demonstrate a clear relationship between HAdV infection and alterations in PCT and CRP which should be taken into account in paediatric patient management.

SUBMITTER: Gomez de Ona C

PROVIDER: S-EPMC8193001 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature

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Publications

Alterations in biochemical markers in adenovirus infection.

Gómez de Oña Constanza C Alvarez-Argüelles Marta E ME Rojo-Alba Susana S Casares Helena H Arroyo Mireia M Rodríguez Julián J de Oña María M Melón Santiago S

Translational pediatrics 20210501 5

<h4>Background</h4>Analyze possible relationships between HAdV and markers for inflammation, specifically the C-reactive protein (CRP) and procalcitonin (PCT) tests, along with other haematological markers.<h4>Methods</h4>Retrospective study of 487 children presenting with fever and/or acute respiratory symptoms in the Paediatric Emergency Department. Analyses included viral presence/absence (both HAdV and other respiratory viruses) in respiratory exudates, CRP and PCT alterations in plasma, and ...[more]

PMID: 34189083

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Dataset Information

Alterations in biochemical markers in adenovirus infection.

Background

Methods

Results

Conclusions

Publications

Alterations in biochemical markers in adenovirus infection.

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