Characteristics of the intestinal microbiota and metabolism in infants with extrauterine growth restriction.

ABSTRACT:

Background

Infants with extrauterine growth restriction (EUGR) experience significant postnatal growth restriction in the first week after birth, which indicates a failure of energy absorption. This study aimed to determine the different intestinal microbial species and metabolites between infants with EUGR and those without EUGR.

Methods

A total of 73 infants hospitalized in a neonatal intensive care unit were enrolled and divided into the EUGR group (n=50) and the non-EUGR group (n=23). Fecal samples were collected during hospitalization. Bacterial species and their relative abundance were identified with metagenome sequencing. The metabolites in the feces and blood were identified with a liquid chromatography-mass spectrometry (LC-MS) based non-targeted metabolome.

Res

SUBMITTER: Fan S 

PROVIDER: S-EPMC8193004 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature