Scalable Bio Marker Combinations for Early Stroke Diagnosis: A Systematic Review.

ABSTRACT: Background: Acute stroke treatment is a time-critical process in which every minute counts. Laboratory biomarkers are needed to aid clinical decisions in the diagnosis. Although imaging is critical for this process, these biomarkers may provide additional information to distinguish actual stroke from its mimics and monitor patient condition and the effect of potential neuroprotective strategies. For such biomarkers to be effectively scalable to public health in any economic setting, these must be cost-effective and non-invasive. We hypothesized that blood-based combinations (panels) of proteins might be the key to this approach and explored this possibility through a systematic review. Methods: We followed the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-

SUBMITTER: Baez SC 

PROVIDER: S-EPMC8193128 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature