The effect of mitochondrial transplantation therapy from different gender on inhibiting cell proliferation of malignant melanoma.

ABSTRACT: Today mitochondria are considered much more than a energy plant in cells. Mitochondrial transplantation therapy has been an active research area for treating mitochondria-associated diseases from animal studies to clinical trials. However, the specific mechanism involved in the anti-tumor activity of healthy mitochondria remain to be characterized. Here we investigate the signal mechanism and gender difference of mitochondrial transplantation therapy against malignant melanoma. In the study, we administrated intact mitochondria extracted from mouse livers respectively to the mice bearing malignantly subcutaneous and metastatic melanoma, and identified the signal mechanism responsible for the mitochondrial treatment through transcriptomic analysis. Meanwhile, the efficiency of female mitoch

SUBMITTER: Yu Z 

PROVIDER: S-EPMC8193273 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature