Highly connected, non-redundant microRNA functional control in breast cancer molecular subtypes.

ABSTRACT: Breast cancer is a complex, heterogeneous disease at the phenotypic and molecular level. In particular, the transcriptional regulatory programs are known to be significantly affected and such transcriptional alterations are able to capture some of the heterogeneity of the disease, leading to the emergence of breast cancer molecular subtypes. Recently, it has been found that network biology approaches to decipher such abnormal gene regulation programs, for instance by means of gene co-expression networks, have been able to recapitulate the differences between breast cancer subtypes providing elements to further understand their functional origins and consequences. Network biology approaches may be extended to include other co-expression patterns, like those found between genes and non-codin

SUBMITTER: de Anda-Jauregui G 

PROVIDER: S-EPMC8193465 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature