Abnormalities of intrinsic brain activity in essential tremor: A meta-analysis of resting-state functional imaging.

ABSTRACT: Neuroimaging studies using a variety of techniques have demonstrated abnormal patterns of spontaneous brain activity in patients with essential tremor (ET). However, the findings are variable and inconsistent, hindering understanding of underlying neuropathology. We conducted a meta-analysis of whole-brain resting-state functional neuroimaging studies in ET compared to healthy controls (HC), using anisotropic effect-size seed-based d mapping, to identify the most consistent brain activity alterations and their relation to clinical features. After systematic literature search, we included 13 studies reporting 14 comparisons, describing 286 ET patients and 254 HC. Subgroup analyses were conducted considering medication status, head tremor status, and methodological factors. Brain activity in

SUBMITTER: Lan H 

PROVIDER: S-EPMC8193520 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature