Human immune deficiency virus-related structural alterations in the brain are dependent on age.

ABSTRACT: Currently, it is still unknown whether human immune deficiency virus (HIV)-related structural alterations in the brain are dependent on age. With people living with HIV at different ages, we aim to investigate age-specific structural alterations in HIV patients. Eighty-three male HIV patients and eighty-three age-matched male controls were enrolled, and high-resolution T1 weighted images were collected and analyzed with four morphological metrics. Then, statistical analyses were respectively conducted to ascertain HIV effects, age effects, and medication effects in brain structure of HIV patients, and the relationship with neuropsychological evaluations were further explored. Finally, discriminative performances of these structural abnormalities were quantitatively testified with three mac

SUBMITTER: Zhao J 

PROVIDER: S-EPMC8193536 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature