Ontology highlight
ABSTRACT:
SUBMITTER: Kim CM
PROVIDER: S-EPMC8193537 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Kim Chan-Mi CM Montal Victor V Diez Ibai I Orwig William W Sepulcre Jorge J
Human brain mapping 20210506 10
Amyloid-beta (Aβ) plaques and tau neurofibrillary tangles are pathological hallmarks of Alzheimer's disease (AD); their contribution to neurodegeneration and clinical manifestations are critical in understanding preclinical AD. At present, the mechanisms related to Aβ and tau pathogenesis leading to cognitive decline in older adults remain largely unknown. Here, we examined graph theory-based positron emission tomography (PET) analytical approaches, within and between tau and Aβ PET modalities, ...[more]