Dataset Information

Sleep during menopausal transition: a 10-year follow-up.

ABSTRACT: A 10-year observational follow-up study to evaluate the changes in sleep architecture during the menopausal transition. Fifty-seven premenopausal women (mean age 46 years, SD 0.9) were studied at baseline and after a 10-year follow-up. At both time points, polysomnography (PSG) was performed, and the serum follicle-stimulating hormone (S-FSH) concentration was measured. Linear regression models were used to study the effects of aging and menopause (assessed as change in S-FSH) on sleep. After controlling for body mass index, vasomotor, and depressive symptoms, higher S-FSH level was associated with longer sleep latency (B 0.45, 95% confidence interval [CI]: 0.07 to 0.83). Aging of 10 years was associated with shorter sleep latency (B -46.8, 95% CI: -77.2 to -16.4), shorter latency to stage 2 sleep (B -50.6, 95% CI: -85.3 to -15.9), decreased stage 2 sleep (B -12.4, 95% CI: -21.4 to -3.4), and increased slow-wave sleep (B 12.8, 95% CI: 2.32 to 23.3) after controlling for confounding factors. This study suggests that PSG measured sleep of middle-aged women does not worsen over a 10-year time span due to the menopausal transition. The observed changes seem to be rather age- than menopause-dependent.

SUBMITTER: Kalleinen N

PROVIDER: S-EPMC8193555 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature

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Sleep during menopausal transition: a 10-year follow-up.

Kalleinen Nea N Aittokallio Jenni J Lampio Laura L Kaisti Matti M Polo-Kantola Päivi P Polo Olli O Heinonen Olli J OJ Saaresranta Tarja T

Sleep 20210601 6

<h4>Study objectives</h4>A 10-year observational follow-up study to evaluate the changes in sleep architecture during the menopausal transition.<h4>Methods</h4>Fifty-seven premenopausal women (mean age 46 years, SD 0.9) were studied at baseline and after a 10-year follow-up. At both time points, polysomnography (PSG) was performed, and the serum follicle-stimulating hormone (S-FSH) concentration was measured. Linear regression models were used to study the effects of aging and menopause (assesse ...[more]

PMID: 33326582

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Dataset Information

Sleep during menopausal transition: a 10-year follow-up.

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Sleep during menopausal transition: a 10-year follow-up.

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