Comparison of transmural healing and mucosal healing as predictors of positive long-term outcomes in Crohn's disease.

ABSTRACT:

Background

Transmural healing (TH) is being increasingly recognized for reflecting deep remission in Crohn's disease (CD). The long-term clinical significance of achieving TH is still not fully known. We aimed to evaluate TH as a predictor of long-term positive outcomes using intestinal ultrasonography (US), with comparison with the established endpoint mucosal healing (MH).

Methods

CD patients were consecutively recruited from September 2015 to August 2018 at a single tertiary hospital. All patients were evaluated at baseline and followed up at 6 months prospectively with a guideline-based treatment regimen. Achieving TH/MH or not was evaluated by US/colonoscopy at the first follow-up. Long-term outcomes including steroid-free clinical remission (CR), drug escalation, hospi

SUBMITTER: Ma L 

PROVIDER: S-EPMC8193655 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature