Effect of basal forebrain somatostatin and parvalbumin neurons in propofol and isoflurane anesthesia.

ABSTRACT:

Aims

The basal forebrain (BF) plays an essential role in wakefulness and cognition. Two subtypes of BF gamma-aminobutyric acid (GABA) neurons, including somatostatin-expressing (GABA^SOM ) and parvalbumin-positive (GABA^Parv ) neurons, function differently in mediating the natural sleep-wake cycle. Since the loss of consciousness induced by general anesthesia and the natural sleep-wake cycle probably share similar mechanisms, it is important to clarify the accurate roles of these neurons in general anesthesia procedure.

Methods

Based on two transgenic mouse lines expressing SOM-IRES-Cre and PV-IRES-Cre, we used a combination of genetic activation, inactivation, and chronic ablation approaches to further explore the behavioral and electroencephalography (E

SUBMITTER: Cai S 

PROVIDER: S-EPMC8193699 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature